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Laboratory of Functional and Molecular Imaging
Alan P. Koretsky, Ph.D., Senior Investigator
Dr. Koretsky received his S.B. degree from the Massachusetts Institute of
Technology and Ph.D. from the University of California at Berkeley. He
performed postdoctoral work in the NHLBI at NIH studying regulation of
mitochondrial metabolism using optical and NMR techniques. Dr. Koretsky spent
twelve years on the faculty in the Department of Biological Sciences at Carnegie
Mellon University where he was the Eberly Professor of Structural Biology and
Chemistry. In summer 1999, he moved to NINDS as Chief of the Laboratory of
Functional and Molecular Imaging and Director of the NIH MRI Research Facility.
Dr. Koretsky's laboratory is interested in two main areas. They are actively
developing novel imaging techniques to visualize brain function and study the
regulation of cellular energy metabolism combining molecular genetics with
non-invasive imaging tools.
Staff:
- Ms. Nadia Bouraoud, Contractor, 301-451-9938 bouraoudn@ninds.nih.gov
- Dr. Der-Yow Chen, Ph.D., Research Fellow, 301-594-7314 chendy@ninds.nih.gov
- Dr. Yun Chen, Ph.D., Guest Researcher, 301-402-1329 chenyun2@ninds.nih.gov
- Dr. Richard Conroy, Ph.D., Contractor, 301-594-7310 conroyri@ninds.nih.gov
- Mr. Sam Day, Pre-doctoral IRTA, 301-402-9709 daysam@ninds.nih.gov
- Dr. Steve Dodd, Ph.D., Staff Scientist, 301-402-0389 doddst@ninds.nih.gov
- Mr. Samuel Hou, Contractor, 301-594-7313 houcs@ninds.nih.gov
- Mrs. Kathy Ireland-Pardini, Office Manager, 301-594-2133 kathyi@ninds.nih.gov
- Ms. Mary Kiganda, M.S., Biologist, 301-435-7945 kigandam@ninds.nih.gov
- Dr. Hellmut Merkle, Ph.D., Staff Scientist, 301-594-7306 merkleh@ninds.nih.gov
- Dr. Joseph Murphy-Boesch, Ph.D., Staff Scientist, 301-594-1305 murphyboeschj@ninds.nih.gov
- Mr. Steven Newman, Contractor, 301-402-9456 newmans2@ninds.nih.gov
- Ms. Ana Paz, Contractor, 301-451-1863 paza@ninds.nih.gov
- Dr. Chunqi Qian, Ph.D., Contractor, 301-435-2146 qianc2@ninds.nih.gov
- Dr. Galit Saar, Ph.D., Visiting Fellow, 301-451-9913 saarg@ninds.nih.gov
- Ms. Kathy Sharer, Research Assistant, 301-402-9652 sharerk@ninds.nih.gov
- Dr. James Sumner, Ph.D., IRTA Fellow, 301-594-0365 sumnerja@ninds.nih.gov
- Dr. Shumin Wang, Ph.D., Staff Scientist, 301-402-0286 wangshu@ninds.nih.gov
- Dr. Xin Yu, Ph.D., Research Fellow, 301-594-7311 yuxin@ninds.nih.gov
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Research Interests:
The Functional and Molecular Imaging Section has two major research interests. One is to develop novel functional and molecular imaging techniques to study brain structure and function. Emphasis is on MRI but some optical imaging is performed as well. Current areas of interest are to extend spatial resolution and understand the relation of functional MRI to neuronal architecture. New imaging tools are being developed to image calcium influx and gene expression non-invasively in the mouse brain.
The second major research area is cellular energetics. In particular, we are interested in the role of the enzyme creatine kinase and regulation of mitochondrial metabolism. This work relies on combining non-invasive imaging tools and molecular genetics in the mouse to study mitochondrial function in vivo. Current areas of interest are to determine the role of creatine kinase in cell growth and death. We are also interested in characterizing changes in the mitochondrial proteome during changes in mitochondrial metabolism using novel two-dimensional gel electrophoresis techniques.
LFMI website http://www.lfmi.ninds.nih.gov/
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Selected Publications:
- K. Chuang, A.P. Koretsky (2006) Improved Neuronal Tract Tracing Using Manganese Enhanced Magnetic Resonance Imaging with Fast T1 Mapping, Magnetic Resonance in Medicine 55, 604-611.
- E.M. Shapiro, K. Sharer, Skrtic, A.P. Koretsky (2006) In Vivo Detection of Single Cells By MRI, Magnetic Resonance in Medicine 55, 242-249.
- S.D. Keilholz, A.C. Silva, M. Raman, H. Merkle, A.P. Koretsky (2006) BOLD and CBV-Weighted Functional Magnetic Resonance Imaging of the Rat Somatosensory System, Magnetic Resonance in Medicine 55, 316-324.
- I. Aoki, Y. Takahashi, K. Chuang, A.C. Silva, T. Igarashi, C. Tanaka, R.W. Childs, A.P. Koretsky (2006) Cell Labeling for Magnetic Resonance Imaging with the T1 Agent Manganese Chloride, NMR in Biomedicine 19, 50-59.
- O. Rodriguez, S. Fricke, C. Chien, L. Dettin, J. Vanmeter, E.M. Shapiro, H. Dai, M. Casimiro, L. Lleva, J. Dagata, M.D. Johnson, M.P. Lisanti, A.P. Koretsky, C. Albanese (2006) Contrast-Enhanced in Vivo Imaging of Breast and Prostate Cancer Cells by MRI, Cell Cycle 5, 113-119.
- U. Himmelreich, R. Weber, P. Ramos-Cabrer, S. Wegener, K. Kandal, E.M. Shapiro, A.P. Koretsky, M. Hoehn (2005) Improved Stem Cell MR Detectability in Animal Models By Mdification of the Inhalation Gas, Molecular Imaging 4, 104-109.
- J. Lee, A.C. Silva, H. Merkle, A.P. Koretsky (2005) Manganese-Enhanced Magnetic Resonance Imaging of Mouse Brain After Systemic Administration of MnCI2: Dose Dependent and Temporal of T1 Contrast, Magnetic Resonance in Medicine 53, 640-648.
All Selected Publications
Contact Information:
Dr. Alan P. Koretsky
NIH/NINDS/LFMI
10 Center Drive, MSC 1065
Building 10, Room B1D728
Bethesda, MD 20892-1065
Telephone: 301-402-9659 office,
301-402-9659 laboratory,
301-480-2558 fax
Email: koretskya@ninds.nih.gov
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