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NIH Neuroscience Faculty

Laboratory of Functional and Molecular Imaging

Photo of Dr. Alan P. Koretsky, Laboratory of Functional and Molecular Imaging, NINDS

Alan P. Koretsky, Ph.D., Senior Investigator
Dr. Koretsky received his B.S. degree from the Massachusetts Institute of Technology and Ph.D. from the University of California at Berkeley. He performed postdoctoral work in the NHLBI at NIH studying regulation of mitochondrial metabolism using optical and NMR techniques. Dr. Koretsky spent twelve years on the faculty in the Department of Biological Sciences at Carnegie Mellon University where he was the Eberly Professor of Structural Biology and Chemistry. In summer 1999, he moved to NINDS as Chief of the Laboratory of Functional and Molecular Imaging and Director of the NIH MRI Research Facility. Dr. Koretsky's laboratory is interested in two main areas. They are actively developing novel imaging techniques to visualize brain function and study the regulation of cellular energy metabolism combining molecular genetics with non-invasive imaging tools.

Staff:

Research Interests:

The Functional and Molecular Imaging Section has two major research interests. One is to develop novel functional and molecular imaging techniques to study brain structure and function. Emphasis is on MRI but some optical imaging is performed as well. Current areas of interest are to extend spatial resolution and understand the relation of functional MRI to neuronal architecture. New imaging tools are being developed to image calcium influx and gene expression non-invasively in the mouse brain.

The second major research area is cellular energetics. In particular, we are interested in the role of the enzyme creatine kinase and regulation of mitochondrial metabolism. This work relies on combining non-invasive imaging tools and molecular genetics in the mouse to study mitochondrial function in vivo. Current areas of interest are to determine the role of creatine kinase in cell growth and death. We are also interested in characterizing changes in the mitochondrial proteome during changes in mitochondrial metabolism using novel two-dimensional gel electrophoresis techniques.

LFMI website http://www.lfmi.ninds.nih.gov/

Selected Publications:

  • T.C, Hu, K.H. Chuang, N. Yanasak, and A.P. Koretsky (2011) Relationship Between Blood and Myocardial Manganese Levels During Manganese-Enhanced MRII (MERI) with T1 Mapping in Rats, NMR Biomed 24, 46-53.
  • G. Zabow, S. J. Dodd, E. Shapiro, J. Moreland, and A.P. Koretsky (2011) Microfabricated High-Moment Micrometer Sized MRI Contrast Agents, Magn Resonan. Med 65, 645-655.
  • Y. Chen, S. Guzik, J.P. Sumner, J. Moreland, and A.P. Koretsky (2011) Magnetic Manipulation of Actin Orientation, Polymerization and Gliding on Myosin using Superparamagnetc Iron Oxide Particles, Nanotechnology 22.
  • S.E. Day, M.I. Kettunen, M.K. Cherukuri, J.B, Michell, M.J. Lizak, H.D. Morris, S. Matsumoto, A.P. Koretsky, and K.M. Brindle (2011) Detecting Response of Rat C6 Glioma Tumors to Radiotherapy using Hyperpolarized [1-(13)C]pyruvate and (13)C Magnetic Resonance Spectroscopic Imaging , Magn Resonan Med 65, 557-563.
  • X. Yu, S. Wang, D-Y Chen, S. Dodd, A. Goloshevsky, and A.P. Koretsky (2010) 3D Mapping of Somatotopic Reorganization with Small Animal Functional MRI, Neuroimage 49, 1667-1676.
  • J.P. Munasinghe, M. Banerjee, M.T. Acosta, M. Banks, A. heffer, A.C. Silva, A.P. Koretsky, W.H. Theodore (2010) Arterial Spin Labeling Demonstrates that Focal Amygdalar Glutamatergic Agonist Infusion Leads to Rapid Diffuse Cerebral Activation, Acta Neurolo Scand 121, 209-216.
  • K-H Chuang, L. Belluscio, and A.P. Koretsky (2010) In vivo Detection of Individual Glomeruli in the Rodent Olfactory Bulb Using Manganese Enhanced MRI, Neuroimage 49, 1350-1356.

All Selected Publications

Contact Information:
Dr. Alan P. Koretsky
NIH/NINDS/LFMI
10 Center Drive, MSC 1065
Building 10, Room B1D728
Bethesda, MD 20892-1065

Telephone: 301-402-9659 office, 301-402-9659 laboratory, 301-480-2558 fax
Email: koretskya@ninds.nih.gov