Cellular and Developmental Neurobiology Section
Susan Wray, Ph.D., Senior Investigator
Dr. Wray received her B.A. degree from Middlebury College and her M.S, and Ph.D. degrees from University of Rochester School of Medicine & Dentistry where she worked on development of neuroendocrine systems associated with puberty. She continued her work on neuroendocrine systems as a postdoctoral fellow with Harold Gainer in NICHD. In 1992 she became a faculty member of NINDS as a Unit Chief in the Laboratory of Neurochemistry and in 1999 became Chief of the newly created Cellular and Developmental Neurobiology Section. She is a council member of the International Society of Neuroendocrinology and a founding member of the American Neuroendocrine Society. Dr. Wray's laboratory is studying developmental cues underlying neuronal migration, and neurogenesis and regulation of neuroendocrine cells essential for reproduction.
- Stephanie Constantin, Ph.D., Contract Scientist firstname.lastname@example.org
- Aloa Lamarca Dams, Ph.D., Postdoctoral Visiting Fellow email@example.com
- Ernest Ekunseitan, Student firstname.lastname@example.org
- Ellen Flannery, Ph.D., Postdoctoral Fellow email@example.com
- Ulrike Klenke, Ph.D., Postdoctoral Fellow firstname.lastname@example.org
- Brandon Pope, B.S., Postbaccalaureate IRTA email@example.com
- Hudson Stoner, B.A., Postbaccalaureate IRTA firstname.lastname@example.org
- Carol Taylor-Burds, Ph.D., Postdoctoral Fellow email@example.com
- Eudorah Vital, Student firstname.lastname@example.org
Our research addresses critical neurobiological issues such as phenotypic commitment and mechanisms involved in neuronal migration. Projects focus on craniofacial development, differentiation and migration of GnRH cells, and olfactory axon outgrowth. This system is a model for neurons exhibiting axophilic migration. Research includes: 1) signals for proper craniofacial development, 2) guidance factors that modulate neuronal migration and 3) intracellular signaling controlling cell movement and corresponding changes in cytoskeletal elements. In addition, the mechanisms regulating GnRH neuronal activity, including peptide secretion are being examined to decipher the cellular characteristics underlying neuroendocrine function and pulsatile secretion. We take advantage of the physiology of the GnRH system by examining the molecular and cellular properties of GnRH neuronal activity at different developmental, metabolic and/or reproductive states.
Research models include nasal explants, slice cultures, immortalized GnRH cell lines, and normal, cre/lox and transgenic mice. Approaches include videomicroscopy, calcium imaging, electrophysiology, immunocytochemistry, in situ histochemistry, single-cell PCR, and subtractive cDNA screening. Together, these models and approaches are used to manipulate the GnRH system.
- Hutchins BI, Klenke U, Wray S (2013) Calcium release-dependent actin flow in the leading process mediates axophilic migration, J. Neuroscience 33, 11361-71.
- Forni PE, Bharti K, Flannery E, Shimogori T, Wray S (2013) The indirect role of FGF8 in defining neurogenic niches of the olfactory/GnRH systems, J. Neuroscience 33, 19620-19634.
- Forni, PE, Wray, S (2012) Neural Crest and olfactory system: new prospective and controversies , Molecular Neurobiology .
- Casoni F, Hutchins BI, Donohue D, Fornaro M, Condie BG, Wray S (2012) SDF and GABA Interact to Regulate Axophilic Migration of GnRH-1 Neurons, Journal of Cell Science .
- Bashour N, Wray S (2012) Progesterone directly and rapidly inhibits GnRH neuronal activity via progesterone receptor membrane component 1, Endocrinology .
- Forni P, Fornaro M, Guenette S, Wray S (2011) A role for Fe65 in controlling GnRH-1 neurogenesis, J. Neuroscience .
- Forni PE, Taylor-Burds C, Melvin S, Williams T, Wray S (2011) Neural Crest and Ectodermal Cells Intermix in the Nasal Placode to give rise to GnRH-1 Neurons, Sensory Neurons and Olfactory Ensheathing Cells, J. Neuroscience .
Dr. Susan Wray
Cellular and Developmental Neurobiology Section, NINDS
Porter Neuroscience Research Center
Building 35, Room 3A-1012
35 Convent Drive, MSC 3703
Bethesda, MD 20892-3703
Telephone: 301-496-6646 office, 301-496-8129 laboratory, 301-496-8578 fax