Cellular and Developmental Neurobiology Section
Susan Wray, Ph.D., Senior Investigator
Dr. Wray received her B.A. degree from Middlebury College and her M.S, and Ph.D. degrees from University of Rochester School of Medicine & Dentistry where she worked on development of neuroendocrine systems associated with puberty. She continued her work on neuroendocrine systems as a postdoctoral fellow with Harold Gainer in NICHD. In 1992 she became a faculty member of NINDS as a Unit Chief in the Laboratory of Neurochemistry and in 1999 became Chief of the newly created Cellular and Developmental Neurobiology Section. She is a council member of the International Society of Neuroendocrinology and a founding member of the American Neuroendocrine Society. Dr. Wray's laboratory is studying developmental cues underlying neuronal migration, and neurogenesis and regulation of neuroendocrine cells essential for reproduction.
- Ebony Argaez, Special Volunteer firstname.lastname@example.org
- Paul Cheng, B.S., Postbaccalaureate IRTA email@example.com
- Kayla Correia, B.S., Postbaccalaureate IRTA firstname.lastname@example.org
- Ellen Flannery, Ph.D., Postdoctoral Fellow email@example.com
- Paolo Forni, Ph.D., Postdoctoral Fellow firstname.lastname@example.org
- B. Ian Hutchins, Ph.D., Postdoctoral Fellow email@example.com
- Ulrike Klenke, Ph.D., Postdoctoral Fellow firstname.lastname@example.org
- Brandon Pope, B.S., Postbaccalaureate IRTA email@example.com
- Sarah Shangraw, B.S., Postbaccalaureate IRTA firstname.lastname@example.org
- Carol Taylor-Burds, Ph.D., Postdoctoral Fellow email@example.com
Our ability to systematically manipulate the molecular and cellular biology of the developing LHRH system opens the route to understanding critical neurobiological issues such as phenotypic commitment and mechanisms involved in neuronal migration. In addition, the mechanisms regulating LHRH gene and peptide expression, as well as peptide secretion are being examined to decipher the cellular characteristics underlying neuroendocrine function.
Research models include nasal explants, hypothalamic slice cultures, immortalized LHRH cell lines, and normal and transgenic animals. Multidisciplinary approaches are used to: 1) localize cell surface components which act as molecular guides for neuronal migration, 2) identify neuronal phenotypes which are derived from olfactory placode and the lineage relationship between them and, 3) create single cell libraries from neurons at different developmental stages for isolation of candidate ‘migrational’ or ‘differentiation’ genes and 4) measuring changes in LHRH mRNA levels and LHRH secretion determine cellular properties of LHRH cells underlying pulsatile secretion.
- Forni, PE, Wray, S (2012) Neural Crest and olfactory system: new prospective and controversies , Molecular Neurobiology .
- Casoni F, Hutchins BI, Donohue D, Fornaro M, Condie BG, Wray S (2012) SDF and GABA Interact to Regulate Axophilic Migration of GnRH-1 Neurons, Journal of Cell Science .
- Bashour N, Wray S (2012) Progesterone directly and rapidly inhibits GnRH neuronal activity via progesterone receptor membrane component 1, Endocrinology .
- Forni P, Fornaro M, Guenette S, Wray S (2011) A role for Fe65 in controlling GnRH-1 neurogenesis, J. Neuroscience .
- Forni PE, Taylor-Burds C, Melvin S, Williams T, Wray S (2011) Neural Crest and Ectodermal Cells Intermix in the Nasal Placode to give rise to GnRH-1 Neurons, Sensory Neurons and Olfactory Ensheathing Cells, J. Neuroscience .
- Constantin S, Klenke U, Wray S (2010) The calcium oscillator of GnRH-1 neurons is developmentally regulated, Endocrinology .
- Metz H, Wray S (2010) Use of mutant mouse lines to Investigate origin of GnRH-1 neurons: lineage independent of the adenohypophysis, Endocrinology .
Dr. Susan Wray
Cellular and Developmental Neurobiology Section, NINDS
Porter Neuroscience Research Center
Building 35, Room 3A-1012
35 Convent Drive, MSC 3703
Bethesda, MD 20892-3703
Telephone: 301-496-6646 office, 301-496-8129 laboratory, 301-496-8578 fax