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Stroke Diagnostics and Therapeutics Section
Steven Warach, M.D., Ph.D., Senior Investigator
Dr. Warach received his Ph.D. in Psychology-Neuroscience from Michigan State University and his M.D. from Harvard Medical School. After completing residency at the Harvard-Longwood Neurology Training program, he was appointed to the Harvard Medical School faculty in Neurology and Radiology and became the founding director of the Division of Cerebrovascular Diseases at Beth Israel Hospital, Boston. He is board certified in Neurology, with subspecialty certification in Vascular Neurology. In 1999, Dr. Warach was recruited to the NINDS Division of Intramural Research to create a translational research program in acute stroke, establishing the Section of Stroke Diagnostics and Therapeutics, which is a member of the NINDS SPOTRIAS network of stroke translational research centers. The Section conducts clinical research at the Stroke Centers of Suburban Hospital in Bethesda, Maryland and Washington Hospital Center in the District of Columbia, where the NINDS has placed stroke teams and MRI research facilities. Further to its educational mission, the Section offers ACGME accredited Vascular Neurology fellowship training.
Dr. Warach led research efforts that pioneered the routine clinical use of diffusion and perfusion MRI in ischemic stroke, performed seminal studies defining the human ischemic penumbra with MRI, and introduced innovative uses of MRI into stroke clinical trial design. The Section's current research focus is on novel diagnostic and therapeutic approaches to acute brain injury: acute ischemic stroke, blood brain barrier disruption and traumatic brain injury. The Section also conducts laboratory research in stroke, with experimental models closely approximating clinical imaging and clinical trial variables, providing reciprocal influences between the bench and bedside investigations.
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Staff:
- Dr. Li An, Ph.D., Staff Scientist, 301-896-2882 anl@ninds.nih.gov
- Dr. Krishna Dani, Special Volunteer, 202-877-3124 danika@ninds.nih.gov
- Lisa Davis, R.N., Nurse, 301-435-7659 davisl@ninds.nih.gov
- Dr. Erica Henning, Ph.D., Postdoctoral Fellow, 301-435-1929 henninge@ninds.nih.gov
- Daymara Hernandez, B.A., Postbaccalaureate IRTA, 301-435-8883 daymara.hernandez@nih.gov
- Karri Hester, B.A., Research Assistant, 202-877-8182 karri.hester@nih.gov
- Mayur Joshi, Web Developer / Graphic Desginer, 301-435-3002 mayur.joshi@nih.gov
- Dr. Alexander Katcheves, M.D., Clinical Fellow, 301-435-9321 alex.katcheves@nih.gov
- Katherine Ku, B.S., Postbaccalaureate IRTA, 301-402-9039 kuk2@ninds.nih.gov
- Dr. Kara Kuntz-Melavage, Ph.D., Post-Doctoral IRTA kuntzmelcavagkl@ninds.nih.gov
- Dr. Lawrence Latour, Ph.D., Staff Scientist, 301-496-0463 latourl@ninds.nih.gov
- Ms. Shoshanna Levine, Research Assistant, 301-896-2944 levinesh@ninds.nih.gov
- Dr. Mitesh Lotia, Contractor, 202-877-8180 mitesh.lotia@nih.gov
- Dr. Marie Luby, Ph.D., Contractor, 301-435-3002 lubym@ninds.nih.gov
- Patricia Lyall, Program Specialist, 301-435-2395 lyallp@ninds.nih.gov
- Dr. John Lynch, D.O., Staff Clinician, 301-896-7547 lynchj@mail.nih.gov
- Sydnee Mahn, Secretary, 301-496-0067 mahnsc@ninds.nih.gov
- Raymond Mirasol, HHMI Scholar, 301-496-0798 raymond.mirasol@nih.gov
- Teresa Morella, Nurse, 301-896-2654 teresa.morella@nih.gov
- Dr. Zurab Nadareishvili, M.D., Ph.D., Clinical Fellow, 301-435-9321 zurab.nadareishvili@nih.gov
- Dr. Carsten Ritter, M.D., Clinical Fellow, 301-435-9321 carsten.ritter@nih.gov
- Leslie Shupenko, B.S., M.S, Contractor, 202-877-4019 shupenkol@ninds.nih.gov
- Dr. Shlee Song, Clinical Fellow, 301-435-9321 songs3@ninds.nih.gov
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Research Interests:
1) Imaging the pathophysiology of acute human stroke
2) Stroke clinical trials
3) Imaging and biomarkers for drug development in stroke
Clinical Protocols:
- Evaluation, Pathogenesis and Treatment of Patients with Cerebrovascular Disease 01-N-0007
Selected Publications:
- Merino JG, Latour LL, An L, Hsia AW, Kang DW, Warach S. (2008) Reperfusion half-life: a novel pharmacodynamic measure of thrombolytic activity, Stroke 39, 2148-2150.
- Gaudinski MR, Henning EC, Miracle A, Luby M, Warach S, Latour LL (2008) Establishing final infarct volume: stroke lesion evolution past 30 days is insignificant., Stroke 39, 2765-2768.
- Merino J, Latour LL, Todd J, Luby M, Schellinger P, Kang DW, Warach S (2007) Lesion volume change after treatment with tissue plasminogen activator can discriminate clinical responders from non-responder , Stroke 38, 2919-2923.
- Chalela J, Kidwell C, Nentwich L, Butman J, Demchuk A, Hill M, Patronas N, Latour LL, Warach S (2007) Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison , The Lancet 369, 293-298.
- Luby M, Warach S (2007) Reliability of MRI PWI-DWI Mismatch Measurement Methods, American Journal of Neuroradiology 28, 1674-1678.
- Kang DW, Chalela JA, Dunn W, Warach S (2005) MRI screening prior to standard tPA therapy is feasible and safe, Stroke 36, 1939-1943.
- Latour LL, Kang DW, Ezzeddine MA, Chalela JA, Warach S (2004) Early blood brain barrier disruption in human focal brain ischemia, Annals of Neurology 56(4), 468-477. Full Text/Abstract
All Selected Publications
Contact Information:
Dr. Steven Warach
Stroke Diagnostic and Therapeutic Section
Stroke Branch, NINDS
Building 10, Room B1D733
10 Center Drive, MSC 1063
Bethesda, MD 20892-1063
Telephone: 301-435-9321 office,
301-435-9321 laboratory,
301-480-0413 fax
Email: warachs@ninds.nih.gov
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