Tubulin tyrosine structure reveals adaptation of an ancient fold to bind and modify tubulin. Szyk, A., Deaconescu, AM, Piszczek, G., Roll-Mecak, A. Nature Struct. & Molec. Biol. 8(11): 1250-8. [Pubmed abstract][ cover ]

Microtubule severing enzymes. Roll-Mecak A, McNally, F.J. Curr. Opin. Cell Biol. 2010 Feb 22; 22(1):96-103. [Pubmed abstract]

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin. Roll-Mecak A, Vale RD.Nature. 2008 Jan 17;451(7176):363-7. [Pubmed abstract]

Making more microtubules by severing: a common theme of noncentrosomal microtubule arrays? Roll-Mecak A, Vale RD. J Cell Biol. 2006 Dec 18;175(6):849-51. [Pubmed abstract]

Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2. Padyana AK, Qiu H, Roll-Mecak A, Hinnebusch AG, Burley SK. J Biol Chem. 2005 Aug 12;280(32):29289-99. Epub 2005 Jun 17. [Pubmed abstract]

The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules. Roll-Mecak A, Vale RD. Curr Biol. 2005 Apr 12;15(7):650-5. [Pubmed abstract]

X-ray structure of translation initiation factor eIF2gamma: implications for tRNA and eIF2alpha binding. Roll-Mecak A, Alone P, Cao C, Dever TE, Burley SK. J Biol Chem. 2004 Mar 12;279(11):10634-42. Epub 2003 Dec 19. [Pubmed abstract]

Universal translation initiation factor IF2/eIF5B. Dever TE, Roll-Mecak A, Choi SK, Lee JH, Cao C, Shin BS, Burley SK. Cold Spring Harb Symp Quant Biol. 2001;66:417-24. [Pubmed abstract]

Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity. Shin BS, Maag D, Roll-Mecak A, Arefin MS, Burley SK, Lorsch JR, Dever TE. Cell. 2002 Dec 27;111(7):1015-25. [Pubmed abstract]

X-ray structure of Saccharomyces cerevisiae homologous mitochondrial matrix factor 1 (Hmf1). Deaconescu AM, Roll-Mecak A, Bonanno JB, Gerchman SE, Kycia H, Studier FW, Burley SK. Proteins. 2002 Aug 1;48(2):431-6. [Pubmed abstract]

Engaging the ribosome: universal IFs of translation. Roll-Mecak A, Shin BS, Dever TE, Burley SK. Trends Biochem Sci. 2001 Dec;26(12):705-9. [Pubmed abstract]

X-Ray structures of the universal translation initiation factor IF2/eIF5B: conformational changes on GDP and GTP binding. Roll-Mecak A, Cao C, Dever TE, Burley SK. Cell. 2000 Nov 22;103(5):781-92. [Pubmed abstract]

Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2. Choi SK, Olsen DS, Roll-Mecak A, Martung A, Remo KL, Burley SK, Hinnebusch AG, Dever TE. Mol Cell Biol. 2000 Oct;20(19):7183-91. [Pubmed abstract]

Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2. Lee JH, Choi SK, Roll-Mecak A, Burley SK, Dever TE. [Pubmed abstract]